Posted by Jakeman on June 13, 2006, at 20:00:10
In reply to Selegline posts on psycobabble, 2002, posted by notfred on June 13, 2006, at 19:25:09
Thanks for the info. If I'm not mistaken the Somerset studies on transdermal selegline contradict the conclusions of the study cited below. They said antidepressant effect WAS significant at lower doses, (6mg) based on patient responses on the Hamilton Scale.
warm regards, Jake
> (-)-Deprenyl did not have a statistically significant antidepressant effect
> after three weeks of treatment at doses of 10 mg/d. However, after six weeks and
> at higher doses (averaging about 30 mg/d for the second three weeks),
> (-)-deprenyl was superior to placebo in antidepressant effect with a positive
> response rate of 50% vs 13.6% and with a 41% reduction in the Hamilton
> Depression Rating Scale mean score vs 10% in the placebo-treated group. No
> hypertensive crises were seen. The rate of occurrence of side effects with
> (-)-deprenyl was no greater than with placebo. It was concluded that
> (-)-deprenyl is an effective antidepressant in a dose range where it is
> distinguished by the absence of many of the side effects typical of nonselective
> MAO inhibitors.
>>
poster:Jakeman
thread:655515
URL: http://www.dr-bob.org/babble/20060610/msgs/656619.html