Posted by Jakeman on June 12, 2006, at 20:38:39
In reply to Re: EMSAM doses too low to effect depression ?, posted by notfred on June 11, 2006, at 23:54:31
>But their research does bear out that the delivery system avoids the side effect in question. Higher doses should be OK.
> EMSAM's potential is limited unless docs are willing to prescribe higher doses. It would be >nice to have a MAOI that is free of dietary >restrictions and can be used throughout its therapeutic range.Over time docs may be willing to prescribe higher dosages without imposing the FDA recommended dietary restrictions after they look at the studies and get patients reporting no problems. There's always going to be some guy who will say I ate a big bowl of sauerkraut with a glass of wine and felt fine. People are going to experiment (hopefully cautiously) and maybe not even inform their doctors.
> As to the metabolites, the exclusion of the amphetamines may not be a good thing. They also have MAOI activity and legit use as psyco meds. >The levels were really low to begin with. The MAOI's are effective partly because the effect many things, a dirty med, adding a bit of >meth/amphetamine may be of benefit.It can be a good thing especially if you are lacking in energy and drive. But my hope was that the reduction of amphetamine metabolites would also reduce the oft mentioned side effect of insomnia and irritability. The Emsam data sheet has a chart showing very significant reductions in amphetimine metabolites compared to oral dosing. However many people on this board using Emsam still report those side effects.
warm regards, Jake
poster:Jakeman
thread:655515
URL: http://www.dr-bob.org/babble/20060610/msgs/656168.html