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Re: bupreorphine for depression

Posted by linkadge on June 4, 2006, at 2:51:58

In reply to bupreorphine for depression » MrBrice, posted by pseudoname on June 3, 2006, at 11:22:59

As far as flattening you out, thats a possibility. Opiates are naturally released during certain pleasurable activities. If one starts taking regualar opiates, they often have no need to seek out those pleasurable acitivies anymore.

For instance, social contact increases opiate release. Junkies can become antisocial because they have learned that they can activate the parts of the brain they want without having to interact socially.

I wouldn't classify buprenorphine as a regualar opiate, since as you mentioned it does some atypical stuff.

As a side note, regular opiates tend to decrease neurogenesis, this may be of consequence when considering that most antidepressants increase it.

Ideally an antidepressant restores the brain activity necessary to allow an individual to find pleasure in pleasurable activies. The antidepressant itself should not be short-circuting the pleasure centres, else the user would likely give up on pleasurable activities.

(Don't get me wrong, I'm all up for being connected to a pleasure machiene while the robots do all the work, but it may be a little while for that to take place)


As a side note. SSRI's flatten you out too. I hear a lot about how to avoid marajuanna because it makes you amotivational. In my experience, at least, the amotivational effects of the SSRI's are far stronger than that of marajuanna.

Linkadge



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