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Re: parnate question-dosage?

Posted by Caedmon on May 27, 2006, at 16:25:01

In reply to Re: parnate question-dosage? » deuce224, posted by Crazy Horse on May 27, 2006, at 12:53:49

Maybe you need to get to 80% MAO inhibition first. Take a look at this:

[from CLINICAL PSYCHOPHARMACOLOGY SEMINAR: ANTIDEPRESSANT DOSING, Paul Perry, Ph.D, BCPP, Brian C. Lund, Pharm.D.
http://www.tu.edu/user_files/10/17.html ]

>>Grasso et al (1991) studied five adult patients, 33 to 61 years old who received tranylcypromine (TCP) for management of their affective illness. Each patient was given TCP 20 mg/d for at least one week. Blood levels of TCP were drawn at 0, 14, 20 and 24 hours following the last dose of the drug. Each patient, except for one nonresponding patient who was switched to ECT, was then restarted at 30 mg/d or 40 mg/d for at least one week. Blood samples were drawn at times similar to those for the first set of samples. Platelet MAO activity was measured. From these data, a statistically significant correlation (r2 = 0.60) between % MAO inhibition and TCP dose was found. This relationship was described by equation 3 and presented in figure 2.

% MAOI = 118.8 (log TCP dose) + 98.7 (Eq. 3)

Even though no patient in this study achieved a % MAO inhibition greater than 64.8%, the resulting logarithmic relationship indicates that 80% MAO inhibition can be achieved with a tranylcypromine dose of 0.7 mg/kg/d (p < or = 0.05).>>


So, you might try a dose that corresponds to .7 mg/kg. If that doesn't work, there is evidence of antidepressant efficacy increasing up to 130 mg/day for tranylcypromine, as I recall. Good luck!

- Chris


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