Posted by djmmm on May 27, 2006, at 14:44:11
In reply to one thing Prozac does, not chemical imbalance, posted by Larry Hoover on May 27, 2006, at 8:59:53
> http://news.bbc.co.uk/1/hi/health/4771777.stm
>
> It's not in Pubmed yet.
>
> LarThey published something on this in the NewScientist
http://www.dr-bob.org/babble/20060515/msgs/644661.htmlhttp://www.newscientist.com/article/dn9171-how-prozac-affects-the-brain.html
here is the abstract:
Fluoxetine targets early progenitor cells in the adult brain
Juan M. Encinas, Anne Vaahtokari, and Grigori Enikolopov*
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724
Communicated by James D. Watson, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, March 15, 2006 (received for review January 19, 2006)
Chronic treatment with antidepressants increases neurogenesis in the adult hippocampus. This increase in the production of new neurons may be required for the behavioral effects of antidepressants. However, it is not known which class of cells within the neuronal differentiation cascade is targeted by the drugs. We have generated a reporter mouse line, which allows identification and classification of early neuronal progenitors. It also allows accurate quantitation of changes induced by neurogenic agents in these distinct subclasses of neuronal precursors. We use this line to demonstrate that the selective serotonin reuptake inhibitor antidepressant fluoxetine does not affect division of stem-like cells in the dentate gyrus but increases symmetric divisions of an early progenitor cell class. We further demonstrate that these cells are the sole class of neuronal progenitors targeted by fluoxetine in the adult brain and suggest that the fluoxetine-induced increase in new neurons arises as a result of the expansion of this cell class. This finding defines a cellular target for antidepressant drug therapies.
poster:djmmm
thread:649281
URL: http://www.dr-bob.org/babble/20060525/msgs/649381.html