Posted by linkadge on May 9, 2006, at 17:23:36
In reply to Statistical question on SSRIs - Psychobabble says » linkadge, posted by Squiggles on May 9, 2006, at 17:14:07
I certainly think it is a possibility. Akathesia, for instance may result from overactivation of certain serotonin receptors and a subsequent drop in dopamine release.
If an SSRI has a shorter half life, then the agonism would happen for a shorter length of time during the day. As serotonin levels drop, it might give opportunity for a bit of a dopamine rebound.
A longer half-life drug like fluoxetine, however, might cause more akathesia, since the serotonin agonism is longer lasting allowing less time for dopamine rebound.
Kind of like how seroquel tends to cause fewer movement problems based on the fact that it binds more loosely certain dopamine receptors.
Thats just a theory though.
Linkadge
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