Posted by Squiggles on May 9, 2006, at 17:14:07
In reply to Re: Statistical question on SSRIs - Psychobabble says, posted by linkadge on May 9, 2006, at 17:00:23
> Different halflives of drugs may affect the system differently.
>
> Although paxil and prozac are both taken once a day, the short half life of paxil makes it likely that the user will experience a greater fluctuation in the activity of the serotonin transporter throughout the day. This may result in a more, or less desireable outcome. Ie, a paxil user may get more yin and yang with the system.
>
> Linkadge
I wonder if this difference may not have
contributed to the slight propensity for
agitated depression, contributing to the
desire for suicide in the case of one SSRI
versus another.Looking at the Merck, under Psychopharmacology,
i see that I am really out of my depth - there
are so many biological transformations of the
drug - absorption, elimination, plasma concentration plasma, renal clearance,
receptor binding (wonder if there is unbinding
in clonazepam :-))
etc. etc. - this is a difficult area for me. But
a psychopharmacologist would know. They would
know if one SSRI could have an ennervating or
lasting effect or not in the first few days, depending on half-life.Squiggles
poster:Squiggles
thread:640557
URL: http://www.dr-bob.org/babble/20060504/msgs/641881.html