Posted by Squiggles on May 8, 2006, at 10:54:37
In reply to Statistical question on SSRIs, posted by Squiggles on May 8, 2006, at 8:21:32
The verdict is not out yet, in my opinion.
I'm going to let it rest until Reboxetin
is actually on the market, and is tried
by my friend for treatment-resistant depression- clinical severity. That may take as long as it took lithium to be reintroduced into the market after some people suffered heart attacks from overdose. Imipramine is a hard drug to tolerate,
but the only thing efficient so far.S T A H L's assessment:
In the meantime here is something from
Dr. Stephen M. Stahl, in "Essential Psychopharmacology of Depression and Bipolar
Disorder", p. 100-101:
SNRIs"Although some tricyclic antidepressants (e.g.,
desipramine, maprotilene) block norepinephrine reuptake more potently than serotonin reuptake, even these tricyclics are not really selective,
since they still block alpha 1, histamine 1, and msucarine cholinergic receptors, as do all tricyclics. The first truly selective noradrenergic reuptake inhibitor (NRI) is [REBOXETINE], which lacks these undesirable binding properties....."Thus, [REBOXETINE] is the logical pharmacological complement to the SSRIs--since it provides selective *noradrenergic* reuptake inhibition greater than serotonin reuptake inhibition but without the undesirable binding properties of the tricyclic antidepressants. ....
p. 105
Early indications from the use of [REBOXETINE]
show that its efficacy is at least comparable to that of the tricyclic antidepressants and the SSRIs. In addition, [REBOXETINE] may specifically enhance social functioning, perhaps by converting apathetic responders into full remitters. Furthermore, [REBOXETINE] may be useful for severe depression, for depression unresponsive to other antidepressants, and as an adjunct to serotonergic antidepressants when dual neurotransmitter mechanisms are necessary to treat the most difficult cases."Squiggles
poster:Squiggles
thread:640557
URL: http://www.dr-bob.org/babble/20060504/msgs/641322.html