Posted by yxibow on April 29, 2006, at 0:17:13
In reply to Re: Klono depressing. Need long benzo not depressi » yxibow, posted by ed_uk on April 28, 2006, at 14:12:10
> Hi J
>
> >Interesting... I was about to say why didn't they patent extend Valium but they did... in some obscure countries, not here anyhow... Nordazepam
>
> Clorazepate (Tranxene) is a pro-drug of desmethyldiazepam ie. it works because it's converted to desmethyldiazepam in the body. Clorazepate itself does not appear in the blood. Desmethyldiazepam has a very long half-life, hence Tranxene's long duration of action. As is the case with diazepam (Valium), single isolated doses of clorazepate (Tranxene) tend to be quite short-acting, but repeated doses are cumulative, leading to a long duration of action. After the first week or two, clorazepate and diazepam can generally be given as a single daily dose.
>
> Regards
>
> Ed
Oh don't get me started on Tranxene.... it had to be rx'd 3x a day, definately not a single daily dose. I don't know why the doctor I started with chose a more obscure benzodiazepine. At the time I knew not a lot about them and I went cold turkey eventualy because it became apparent to me and others at the time that I was perhaps losing short term memory. And then the ** of a doctor (different -- they consolidated and eliminated my off campus doctor so all my mental health could be watched in the same place -- the psychologist I liked, the psychiatrist was a pardon the expression feminist b* who didn't particularly seem to like her male patients, especially those who read PDRs) didnt do the immediate thing of giving me back all the Tranxene that I had prescribed. I have permanent muscle spasms in my scalp that arise every now and then. If they took things seriously at the student health place they would have taken muscular movements on my scalp that could be felt by both a doctor and a significant other as something NOT good. And put back the full dose. Until such time as I could slowly taper off. But I'm not anti benzodiazepine. Just anti-past events, things that can't be changed. Or maybe eventually not 9 years later but a couple of decades it will vanish.
poster:yxibow
thread:636282
URL: http://www.dr-bob.org/babble/20060423/msgs/638011.html