Posted by linkadge on April 7, 2006, at 18:04:18
In reply to Re: Drugs versus Psychotherapy - Backlash?, posted by SLS on April 7, 2006, at 17:30:11
Think of it another way. Huntingtons disease is a genetic disorder. That means that without treatment the disease will progress and take over. (Ie, it is endogenious). But, mice who posess HD genes actually benifit from exercise. Yes, that is an endogenious geneticly based disease being modified by the application of exercise.
Ie, mice who possess the Huntingtons gene benifit both symptomatically, and physiologically from exercise. It can delay the progression of many symyptoms. Exercising HD mice loose ballance much later, and also retain weight and brain volume much longer than mice who are sedintary.
I guess my argument is that the disease may be biolocial and endogeniously driven, but one cannot therefore deduce that exercise will have no impact on the course of illness.
It is funny because like in depression and other neurodegeneritive disorders, HD mice posess abnoramlly low levels of BDNF, and exercise can attenuate this decline. Depression and suicidal ideation are big problems in Huntintons. Perhaps due to the way that the disease interacts with the BDNF gene.
www.hdlighhouse.com discusses many agents that can modify the course of Huntintons. They discuss how diferent agents modify BDNF, and how they affect the progression of HD positive mice. They have found that DHA (fish oil) treats Huntintons, Lithium treats huntintons, Exercise treats Huntintons, and how many other agents affect the course of degeneration.
So for somebody to say that exercise cannot treat a depression that is endogeniously driven, may not be accuate at all. Some of the research I believe in (with depression) is how it relates to genes that affect BDNF. One potential gene found in bipolar families 22q. 11 (or something like that) is associated with dramatically decreased BDNF. Bipolar depression is associated with dramatically decreased BDNF.
Exercise alone (in many studies) acutally increases BDNF more than an antidepressant alone.
So if we see recurrent depresson as perhaps degeneritive, then perhaps exercise can modify the long term course of illness.
Linkadge
poster:linkadge
thread:629584
URL: http://www.dr-bob.org/babble/20060403/msgs/630269.html