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Parnate day #13

Posted by Rocket Jackson on March 27, 2006, at 8:52:34

Time for another parnate update. :)

Starting last Wednesday on day #8, I increased the dose from 30mg/day (10mg tid) to 40mg/day (20mg in am, 10mg, 10mg), followed two days later on day #10 to 50mg/day (20mg, 20mg, 10mg), which is my current dose. That day I increased the dose to 50mg/day, I definitely noticed an improvement as far as my social anxiety is concerned. What is typically a pretty difficult and anxious situation for me (going out to dinner with a large group of people with plenty of socializing) ended up being very enjoyable. Though I didn't get the true test via direct questioning from the entire group with all eyes focused on me (a notorious form of torture for me), I nevertheless felt much more comfortable without the need for Klonopin. I don't feel the same "pro-social" effect necessarily at this point like I do with my Klonopin/Provigil combo, but just more relaxed in general.

The next day was a little more equivocal, as was yesterday. I had to speak in my church (another killer) so went ahead and added my usual 1mg of Klonopin (without the Provigil... I'm unsure of how this might interract with the parnate). That did the trick, but unfortunately as is always the case without the Provigil I get pretty tired on the Klonopin within a couple of hours which almost seems to make me feel less social (though still relaxed in a social situation).

So, I'm still wondering if I may need to push my dose up again. I'm tolerating each dose escalation without difficulty, so I'm not worried in that regard. But with most people with social phobia it seems the minimal effective dose is 60mg/day, so I may still be a little subtherapeutic. I'll likely give it another couple of days at 50mg then make the change.

Sleep is still fine as long as my evening dose (third dose of the day) is no later than 7pm. I continue to notice a decrease in appetite and a pretty powerful surge of energy for 2-3 hours after each dose (especially after my morning dose), followed by some fatigue later in the afternoon. I'm a bit orthostatic if I get up too quick, but this is easily correctable by just doing it a little more slowly. And definitely some major league delayed orgasm. This is frustrating but I'll put up with it depending on other benefits from the med. Otherwise, no weight gain (probably a slight loss, though I haven't weighed myself) or problems with food. I stay off the cheese, cured/smoked meats, don't drink alcohol anyway, and watch for soy products. I'm still pretty copious with my caffeine intake... maybe I should check a quick BP after my morning diet pepsi. :)

Anyway, I hope you're all doing well. Thanks for the input. I'll keep my fingers crossed that the benefit I noticed is real and will continue to pass the social tests.

RJ


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poster:Rocket Jackson thread:620646
URL: http://www.dr-bob.org/babble/20060322/msgs/625089.html