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re..Caffeine and P450 » TylerJ

Posted by yxibow on March 5, 2006, at 17:23:25

In reply to CAFFIENE...Good or Bad?, posted by TylerJ on March 5, 2006, at 14:17:03

> CAFFIENE
>
>
> Most of us use caffiene so often that we don't even think of it as a drug. Caffiene can provide an immediate lift that increases energy and stamina, Caffiene can also increase sex drive.
> However, too much caffiene can cause heart palpitations and fatigue.
>
> -Is caffiene safe and effective when combined with antidepressants? I read that many people believe caffiene combined with maoi's make the drugs work better and reduce the chance of poop-out.
>
> -Please let me know your personal experiences with caffiene and any information you can add about positive or negative effects of caffiene. Most pdocs say no caffiene or very little especially if you suffer from anxiety.
>
> Thanks, Tyler


In college I could bring around a double walled thermos with 4 shots of espresso in it. But that's Seattle and everyone there is on a caffeine IV drip. Can't do it now, it aggravates my current primary anxiety complex disorder as well as messing up my GI system (needn't go into details but shall we say urgency of #2) and increasing general anxiety overall.


Caffeine also is an issue with some medications such as Luvox, cimetadine, Cipro, etc, as it can be inhibited at P450 CYP1A2 and possibly CYP3A4, so that the clearance of caffeine is reduced and in extreme cases caffeine toxicity can be developed.

 

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