Posted by linkadge on March 3, 2006, at 16:07:00
In reply to Re: Antidepressants don't work except for when the » Chairman_MAO, posted by SLS on March 3, 2006, at 14:36:12
I honestly don't think we have come anywhere. We are still using the exact same techniques to treat depression as we were 40 years ago. In addition we lack any conlusive evidence whatsoever that these are the mechanisms involved in the etiology of depression.
What does this modern research amount to?
In addition, we are uncovering solid evidence that links depressive disorders to low activity of the serotonin transporter (not to bring up old dirt). Many recent studies are currently baffling scientists because they suggest that depression is actually more common in people who have less acitivity of the serotonin transporter ie people with the (SS) varient of the serotonin transporter, a condition we are effectively reproducing with SSRI's. We have a drug called tianeptine that is as effective as SSRI's yet it works the opposite, leaving scientists reverting back to the old biochemistry kickstart theory of antidepressant action. It's great to marvel, but I still contend that we are clueless.
I see our attempts as pathetic as the assumption that alzheimers is a disease cause by low acetycholine.
Linkadge
poster:linkadge
thread:615349
URL: http://www.dr-bob.org/babble/20060227/msgs/615495.html