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Re: NARDIL + PARNATE!

Posted by Chairman_MAO on February 28, 2006, at 21:44:30

In reply to Re: NARDIL + PARNATE!, posted by JaclinHyde on February 28, 2006, at 3:33:32

I suppose my superb experience with the "new" Nardil was all placebo, right?

Yes, it is made to "AB" specifications now. Yes, I think it is absurd that there can be a 20% variation in the amount of drug per tablet. Yes, I think it is possible that SOME people were affected by the change. Most probably were not.


However:

--90% of all attempts I've heard to explain what exactly is wrong with the "new" Nardil make absolutely no sense pharmacologically.
--Phenelzine sulfate is the active ingredient. If you took phenelzine sulfate in a capsule with no excipients it would work just fine. Your stomach is more than capable of dissolving those tablets. Moreover, the reason it is made as a sulfate salt is so that it survives the polar environment of the stomach and is absorbed properly. It could be compounded with Skittles and would work just as welk (assuming it was stored properly).

Such scaremongering is not helpful. Before you flame me, please back up your claims with a valid and sound argument.

And there is no reason to think that combining Nardil with Parnate would produce untoward reactions per se IF APPROPRIATE DOSAGES ARE USED. However, if MAO inhibition is over around 80-90%, the antidepressant effect is compromised, so this would be counterproductive. Also, unless ace weighs 150kg+, I think the dosages of both are excessive. These drugs are not wholly specific MAO inhibitors at all dosage ranges; many other enzymes can be inhibited as well. Tranylcypromine can induce thrombocytopenia, i.e. low platelet count, blood cannot clot, at toxic dosages.

Anyone considering doing this should have MAO platelet counts measured. Ace: it would be safer if you combined d-amphetamine with Nardil; I know that is what you're going for anyway. You aren't going to gain anything by inhibiting more MAO than 1mg/kg phenelzine already does.

BTW, there is no such thing as a Nirvana pill. Took me a long time to figure that one out as well.


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