Posted by yxibow on February 14, 2006, at 2:23:05
In reply to Re: Whats best for GI problems, posted by linkadge on February 13, 2006, at 20:11:08
> I've been using ginger root, which does have 5-ht3 antagonistic affinity. It has been fairly usefull, but not completely curative.
> It feels like there is a dumb little circut from my brain to my stomach. Most of the time it is just a thought that causes these sharp surges. If my brain waited a few seconds and thought it through, it would probably realize that a shot of gastric juice is not really the way to best remedy the situation.
Interesting -- I checked this out, you're right, it contains a mild 5TH3 affinity antagonist called galanolactone. I'm one of these odd people that likes chewing raw ginger actually, and its cheap as dirt from Trader Joes. I do use it for nausea sporadically if there is a medication change. So this proves then that it probably is not an ulcer because there would be other complications and it wouldn't respond to 5TH3 inhibitors.
As I noted, almost all of the serotonin receptors in your body are located in the stomach region. Why the evolutionary reason I haven't the faintest idea. Very few serotonin receptors make it to the brain. As I speak I have a very mild gastric sense, and I have an anxiety disorder. Maybe like thinking.
It is also probably the reason that SSRIs havent responded for the most part because a number of them are "unclean" and have 5HT3 agonist properties that may go away over time.