Posted by Tomatheus on January 10, 2006, at 19:09:49
In reply to Re: Questions about Wellbutrin » Tomatheus, posted by ed_uk on January 9, 2006, at 14:22:44
> Rasagiline (Azilect) was recently approved in the UK. Are you interested in this drug?
Ed,
I may be interested in it at some point, but I think I'd prefer to try Parnate (again) and Emsam (assuming that it becomes available relatively soon) first before considering rasagiline. I took Parnate for about two weeks and ended up discontinuing it because the afternoon sedation was just interfering with my ability to attend university classes too much. So, I never really gave it much of a chance, and I certainly didn't allow myself to try different dosing schedules to see if I could prevent some of that afternoon sedation. If things don't work out with Nardil, I'll probably try Parnate next and then Emsam. What interests me most about Emsam (as opposed to oral selegiline) is that it actually allows the selegiline to stay at an almost perfectly steady level in the bloodstream over a 24-hour period. As I've mentioned in other posts, I suspect that an MAOI's ability to inhibit the MAO enzymes consistenty over time has a lot to do with its therapeutic benefits. Even though Emsam doesn't inhibit MAO-A to a huge extent, at least it will inhibit both enzymes in a manner that is consistent over time. I still have my doubts about Emsam because I still think it's too selective to MAO-B to help me much, but I may try it, especially if my current Nardil trial and a Parnate trial both prove to be unsuccessful.
And so, if Emsam fails, I'm not sure if I'll still be interested in a drug that's primarily an MAO-B inhibitor, but I might consider it. I know of a source where I could obtain it from if need be.
Thanks for the suggestion.
Tomatheus
poster:Tomatheus
thread:594725
URL: http://www.dr-bob.org/babble/20060108/msgs/597694.html