Posted by blueberry on January 10, 2006, at 6:25:19
In reply to Re: What is the biological pathway... sex and SSRI, posted by law663 on January 9, 2006, at 19:47:29
Actually zyprexa rarely increases prolactin levels. And when it does, it is usually only a little bit and it is usually transitory, falling back to baseline within a few weeks. The most guilty ones for increasing prolactin are risperdal and amisulpride.
As far as blocking DA, it isn't that simple. Even though zyprexa does block some but not all DA receptors, it does so rather weakly, and it also stimulates increased DA levels as an indirect result of blocking 5HT receptors. The DA blockade is rather weak compared to the increased DA release, especially at lower doses.
I tried increasing 5HT in all areas of my brain by taking 5HTP supplements. I have never experienced such severe sexual side effects as I did with 5HTP. Much much worse than SSRIs. For me anyway.
> Humm, that's interesting. I'm suprised to hear about zyrexa as it increases prolactin and blocks DA which is needed for sex. I'm skeptical of the prozac claim b/c of the high prevalence of sex side effects with those on it (and it killed my sex drive) [but appeciate the feedback].
>
> I've often wondered what are the effects of raising 5HT levels in all areas of the brain. we already know that it dramatically changes sleep arcitecture.
poster:blueberry
thread:597032
URL: http://www.dr-bob.org/babble/20060108/msgs/597486.html