Posted by Racer on January 9, 2006, at 12:23:00
In reply to What is the biological pathway... sex and SSRI?, posted by law663 on January 9, 2006, at 7:40:55
I don't know all the details, but it's got to do with receptors -- 5HT2c if I remember correctly, which I probably don't -- in the spinal cord. Since the SSRI affects those receptors, they can't respond properly to sexual pleasure. I think there's some connection to dopamine (in the sense of interfering with normal dopamine transport, because the serotonin is hanging out), but can't remember the details.
What has worked for me, though, is cyproheptidine. It temporarily blocks the effects of the SSRI, thus allowing for a lovely bout of rolling around and screaming. Apparently doesn't work for everyone, but since it's a cheap, benign drug, with few side effects -- standard anti-histimine, so it'll make you sleepy -- and a shortish half life, it's worth trying.
Good luck.
poster:Racer
thread:597032
URL: http://www.dr-bob.org/babble/20060108/msgs/597144.html