Posted by linkadge on December 10, 2005, at 21:07:06
In reply to Re: Dr. Tracy on SSRIs.. » linkadge, posted by Larry Hoover on December 10, 2005, at 17:32:08
>Excepting serotonin syndrome, no demonstrated >condition of excess serotonin is known.
High serotonin *is* implicated in many disorders. From migrane to anorexia. It just depends on who you talk to, and what research you read. Have you not read some of the actual findings relating depression and the SERT transporter?
Apparently, people with the short-short varient of the serotonin transporter have a "higher" lifetime risk of depression. The short-short varient of the serotonin gene codes for a lower reputake of serotonin. These people demonstrate higher levels of serotonin due to this varient in the serotonin transpoter.But please, don't just believe me. Read this link.
http://www.futurepundit.com/archives/001611.html
The SERT transporter is the enzyme that SSRI drugs work to inhibit. Here is direct evidence, linking *low* activity of the serotonin transporter, to depression, and binge drinking.
So I restate. Some research shows that high serotonin is implicated in certain disease states.
>Not high serotonin levels. High activity at >specific serotonin receptors.Just like schizophrenia may be related to high dopamine at certiain receptors, right ? Although, I don't know of too many people immune to stimulant psychosis.
>And anxiolytic. Depends on the receptor.
You are right, but for many, the net effect of taking an SSRI, is not anxiolytic.
>MAO-A is not specific to serotonin. Flooding the >brain with free serotonin does not mimic any >known physiological process.
Taking LSD, doesn't mimic any physiological process. I don't know what you are trying to say?
>Then that is not a serotonin effect. It's a drug >toxic effect.
Thats exactly it. Breggin coined it, not me. "Brain disabling treatments". Rember, I am referring to SSRI's.
Like I said, taking melatonin with fluoxetine largely nullifies the antidepressant responce. That is because, it restors sleep, and does not let the drug interfere with sleep cycles to create its effect. SSRI's simply mimic the antidepressant effects of sleep deprivation.
?? What is premature aging?Lets not be difficult. I think there was an X-Files on it.
>I'm sorry that happened, but LSD is quite a >different drug.There are many similarities, and I am not the first to notice, or propose that.
>I try to stay away from these mechanistic >arguments, because they require that you believe >the premise to believe the conclusion. Petitio >principii.It's quite simple. The higher the functional agonism at 5-ht2a receptors. The higher the probability of visual disturbances as a side effect.
>She doesn't make those arguments. You did.No, I didn't make that connection. She has made it her job to try and explain some of the behaviors that have resulted from the use of the drugs. I am to suppose that her attemps to liken the effects of SSRI's to that of harsher drugs has no relavance to this?
>In the very next breath, she argues that SSRIs >are prophecied in the Bible, and I just stopped >listening at that point.
I would stop listening too. But that doesn't mean I would throw the baby out with the bathwater. It is too bad that the sensationalists are the only ones who get the attention. Goodness knows there are more sensable people saying the same thing.
>Please try to separate from the emotional >appeals, with seemingly plausible arguments, >based on zero evidence. The woman scares me.
Zero evidence? Now that is kind of talk scares me.
Linakdge
poster:linkadge
thread:587690
URL: http://www.dr-bob.org/babble/20051203/msgs/587904.html