Posted by Jedi on November 20, 2005, at 1:50:44
In reply to Re: MAOIs and psycho-surgery » Jedi, posted by Bob on November 19, 2005, at 18:02:08
> Your info is heartening. I assume you are not getting extreme side effects, or otherwise you'd be off of it? If you don't mind me asking, what types of things did you augment Nardil with, assuming that none of the SSRIs are available?
>
> Again, it's not that I am somehow against the MAOIs, just that I've had a bad time with so many meds for so long that I'm real skittish now.
>
> I basically have major depression, major anxiety, and some obsessional/rumination problems.Hi Bob,
I do get side effects from the Nardil. I am on a fairly high dosage of between 75 and 105mg. Most of the side effects have gone away over time. I no longer get orthostatic hypertension. In fact Nardil will decrease borderline hypertension, so that if you are affected with this ailment, another med for this is probably not necessary.The main side effects that are still with me are carbohydrate cravings which cause my weight gain and delayed ejaculation. The weight gain can be controlled with vigorous exercise. When you are severely depressed, forcing yourself to exercise can be very difficult. Weight gain is also a symptom of my atypical depression. The delayed ejaculation has not been much of a problem for me, there are augmentations to handle this, also.
What it comes down to is a choice. I can fight though some minor side effects or lay in bed for 16 hours a day and watch my life and family disappear.
Currently, I am augmenting with 1mg of clonazepam. There is some current research that augmenting with up to 3mg of clonazepam can help resistant depression. I may try this for a month while reducing my Nardil dosage, just to see what happens. I've also augmented with nortriptyline which is the major metabolite of amitriptyline & effects mostly NE. I've used bupropion with Nardil also. This is officially contraindicated but helped with my Nardil induced weight gain. I found the bupropion caused some initial agressiveness but the Nardil counteracted the anxiety producing effects of bupropion. Never augment Nardil or Parnate with an SSRI. They potentiate serotonin in the brain by different pathways. Serotonin syndrome is the result. Anyway Bob, there are many things left to try. It can be a long hard road, but we do what's put in front of us.
Take care,
Jedi
poster:Jedi
thread:579730
URL: http://www.dr-bob.org/babble/20051119/msgs/580556.html