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Re: Amineptine under the tongue (sublingual) sukarno

Posted by ed_uk on November 17, 2005, at 14:03:45

In reply to Re: Amineptine under the tongue (sublingual), posted by sukarno on November 15, 2005, at 19:54:56


>Valium (diazepam) 8mg at 9am and 10mg at 9pm. (I'm currently tapering the dose by 1mg per month. I was on 20mg/day in September, then 19mg/day in October and now 18mg/day.)

That's a great taper. People who rush benzo tapers sometimes end up in a dreadful mess - occasionally taking months or years to recover. Rapid benzo tapers never did anyone any good! Aim for the lowest dose of diazepam which relieves your anxiety/panic - don't force yourself to discontinue it entirely if you still need it for anxiety.

>Ed, does cyclizine help nausea by acting as a dopamine antagonist?

No - it's mechanism of action isn't fully understood, it does act as an antihistamine and anticholinergic though. It also causes the esophageal sphincter to contract. It's usually fairly well tolerated. Cyclizine is widely used in the UK as an antiemetic.

Domperidone (Motilium) might be useful. It's a peripherally acting dopamine antagonist which doesn't cross the blood brain barrier. Is it available in Indonesia? If not, haloperidol (Haldol, Serenace - a potent dopamine D2 antagonist and antiemetic) might be effective at a very low dose eg. 0.5mg every 12 hours. Haloperidol is only suitable for short term use. It's highly unlikely that you'll need an anti-nausea med in the long run anyway.

Kind regards





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