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Re: Amineptine under the tongue (sublingual)

Posted by sukarno on November 15, 2005, at 19:54:56

In reply to Re: Amineptine under the tongue (sublingual) sukarno, posted by tecknohed on November 15, 2005, at 17:47:31

I live in Indonesia. Amineptine was pulled from the market here a few years ago, but I can still get it as there is still leftover stock.

My current drug regimen is:

Stablon (tianeptine) 12.5mg 4x/day

Valium (diazepam) 8mg at 9am and 10mg at 9pm. (I'm currently tapering the dose by 1mg per month. I was on 20mg/day in September, then 19mg/day in October and now 18mg/day.)

Pepcid (famotidine) 40mg 2x/day

My panic attacks and depression are well-controlled but I feel an overwhelming sense of laziness/lack of motivation and apathy, so I'm not sure what is causing that. I also have a very low libido, so those two reasons are why I decided to try amineptine.

When I tried amineptine last time for 3 days, I felt a restoration of my libido and some increase in motivation, but then I felt stomach pain, mild nausea and a burning sensation in my stomach too.

I did try taking amineptine with a full stomach and an antacid... that seemed to help prevent pain in the stomach, but then I felt nauseated.

When I put it under my tongue tonight I experienced a "buzz" which was stronger than my previous experience having taken swallowed it. I felt light-headed/dizzy and light in the limbs. hehheh. I didn't feel a stimulant effect though...but this time I only took 12.5mg instead of 25mg.

Last time it gave me the dizzy and lightweight feeling and a few hours later a stimulant or "activating" effect took hold and continued for at least a day or two. Slightly restless and some anxiety, but no panic attacks.

I guess I'll have to fine-tune the dose.

I'm wondering if amineptine affects me more because both it and tianeptine are metabolised by beta-oxidation in the liver. Wouldn't that cause a drug interaction, boosting the blood levels of both drugs?

I don't want to quit tianeptine though because it is a great anxiolytic in my experience and does work for depression too, although I wouldn't call it a strong antidepressant... more of a "mild" or "light" antidepressant. It didn't worsen my libido. I'm 33 years old and have experienced decreasing libido since I turned 30 or 31.

Those two things concern me a lot.. the low libido and lack of motivation. I'm hoping amineptine can take care of both.

Hey Ed, does cyclizine help nausea by acting as a dopamine antagonist?




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