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Re: Opiates for depression? Squiggles

Posted by jerrympls on November 13, 2005, at 19:04:13

In reply to Re: Opiates for depression?, posted by Squiggles on November 13, 2005, at 18:50:57

> ...
> > Hi Squiggles-
> >
> > I don't know if you've been reading any of my posts - but I am on an opiate for depression. The opiate (hydrocodone) was added to my other depression meds, including Lexapro, Adderall & ativan. So YES, opiates can work with antidepressants.
> >
> > Jerry
> I did not read that Jerry. Thanks - that's
> very good and I will suggest to my friend
> that she consult her doctor about that -
> you may recall the problem we are dealing
> with (witht the present tricyclic) is anhedonia.
> Thanks for that bit of info.
> Squiggles

Here's some research on opiates you may want to take to the doctor. It's what I took to mine. I also have one more really interesting study showing how a doc used oxycontin with success in some patients with treatment-resistant depression.

1: J Clin Psychiatry. 2001 Mar;62(3):205-6.

Treatment of refractory major depression with tramadol monotherapy.

Shapira NA, Verduin ML, DeGraw JD.

Publication Types:
Case Reports

PMID: 11305709 [PubMed - indexed for MEDLINE]

2: Aust N Z J Psychiatry. 2000 Dec;34(6):1032-3.

The efficacy of intramuscular tramadol as a rapid-onset antidepressant.

Spencer C.

Publication Types:
Case Reports

PMID: 11127616 [PubMed - indexed for MEDLINE]

3: Am J Psychiatry. 1999 Dec;156(12):2017.

Treatment augmentation with opiates in severe and refractory major

Stoll AL, Rueter S.

Publication Types:
Case Reports

PMID: 10588427 [PubMed - indexed for MEDLINE]

5: Biol Psychiatry. 1996 Jun 15;39(12):989-90.

Buprenorphine for depression: the un-adoptable orphan.

Callaway E.

Publication Types:

PMID: 8780832 [PubMed - indexed for MEDLINE]

6: Am J Psychiatry. 1996 Jun;153(6):843-4.

Mood alterations and tramadol.

Pinkofsky HB, Woodward RA, Reeves RR.

Publication Types:
Case Reports

PMID: 8633712 [PubMed - indexed for MEDLINE]

8: Biomed Pharmacother. 1996;50(6-7):279-82.

Treatment of depressive syndromes in detoxified drug addicts: use of

Laqueille X, Bayle FJ, Spadone C, Jalfre V, Loo H.

Service Hospitalo-Universitaire de Sante Mentale et de Therapeutique,
Hospitalier Specialise Sainte-Anne, Paris, France.

Depressive syndromes are very frequent in drug-addicted patients. Their
study is particularly difficult on account of the toxic intake which disturbs
the clinical analysis. Methadone has improved our understanding of these
pathologies. In fact, methadone permits treatment of some depressive
disorders typically linked to addiction, such as a motivational symptoms and
depressive mood following intoxication. It brings to the fore the other mood
disorders which are often associated with drug intake.

Publication Types:
Review, Tutorial

PMID: 8952868 [PubMed - indexed for MEDLINE]

9: J Clin Psychopharmacol. 1995 Feb;15(1):49-57.

Buprenorphine treatment of refractory depression.

Bodkin JA, Zornberg GL, Lukas SE, Cole JO.

McLean Hospital, Consolidated Department of Psychiatry, Harvard Medical
Belmont, MA 02178, USA.

Opiates were used to treat major depression until the mid-1950s. The
advent of opioids with mixed agonist-antagonist or partial agonist activity, with
reduced dependence and abuse liabilities, has made possible the reevaluation of
opioids for this indication. This is of potential importance for the population
of depressed patients who are unresponsive to or intolerant of
conventional antidepressant agents. Ten subjects with treatment-refractory,
unipolar, nonpsychotic, major depression were treated with the opioid partial
agonist buprenorphine in an open-label study. Three subjects were unable to
tolerate more than two doses because of side effects including malaise, nausea,
and dysphoria. The remaining seven completed 4 to 6 weeks of treatment and as
a group showed clinically striking improvement in both subjective and
objective measures of depression. Much of this improvement was observed by the end of 1 week of treatment and persisted throughout the trial. Four subjects
achieved complete remission of symptoms by the end of the trial (Hamilton Rating
Scale for Depression scores < or = 6), two were moderately improved, and
one deteriorated. These findings suggest a possible role for buprenorphine
in treating refractory depression.

Publication Types:
Case Reports
Clinical Trial

PMID: 7714228 [PubMed - indexed for MEDLINE]

11: Int Clin Psychopharmacol. 1988 Jul;3(3):255-66.

Current and historical concepts of opiate treatment in psychiatric

Weber MM, Emrich HM.

Max-Planck-Institut fur Psychiatrie, Munchen, Federal Republic of

In recent years psychiatric research has rediscovered the theoretical
and clinical importance of opiates, especially for the understanding of
depressive disorders. However, opiate treatment is not a new therapeutic concept
in psychiatry. The use of opium for "melancholia" and "mania" may be traced to ancient classical medicine. After Paracelsus and Sydenham, the psychiatry of the German Romantic Era widely discussed therapeutic opium use with the Engelken family going on to develop a structured opium treatment of depression in the first half of the nineteenth century. Although the underlying scientific problems of psychiatric opium therapy were never solved, it gained an outstanding position as a practical treatment for over 100 years.

Publication Types:
Historical Article

PMID: 3153713 [PubMed - indexed for MEDLINE]




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