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Re: Remeron and Cortisol - Dexamethasone

Posted by SLS on September 22, 2005, at 21:47:02

In reply to Re: Remeron and Cortisol » Elroy, posted by Elroy on September 22, 2005, at 20:55:12

Hi.

Another alternative to consider would be to employ a short course of dexamethasone: 3-4mg per day for 4 days. This might help reset the HPA axis. I am looking into this treatment for bipolar depression. I would be doing this while continuing with my current drug regime. If it works, I predict that I would need periodic maintenance treatments. Hopefully, the frequency of these treatments would decrease over time. One study suggested that this procedure was preferentially successful to those who were hypercortisolemic.

Just an idea.


- Scott


--------------------------------------

Acta Psychiatr Scand. 1997 Jan;95(1):58-61. Related Articles, Links


Dexamethasone augmentation in treatment-resistant depression.

Dinan TG, Lavelle E, Cooney J, Burnett F, Scott L, Dash A, Thakore J, Berti C.

Department of Psychological Medicine, St Bartholomew's Hospital, London, UK.

A total of 10 patients who fulfilled DSM-III-R criteria for major depression were recruited to the study, each of whom had failed to respond to a 6-week course of treatment with either sertraline or fluoxetine. Each subject had baseline serum cortisol measurements together with a Hamilton depression (HAMD) score. All patients were started on dexamethasone (3 mg daily) for 4 days, while remaining on their antidepressant treatment. Further Hamilton ratings were made on days 5 and 21. Six patients showed a significant improvement, whilst two showed a minimal response. A good clinical response was associated with a high baseline cortisol level.

PMID: 9051162 [PubMed - indexed for MEDLINE]


 

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