Posted by sukarno on September 2, 2005, at 22:14:31
In reply to Re: Stablon (tianeptine) stopped working again » sukarno, posted by Declan on September 1, 2005, at 15:06:56
I think Ed mentioned that I should be tested to see if I am a poor metaboliser. All of the drugs I've tried in the past which were metabolised by CYP2D6 seem to have affected me so strongly even in the lowest doses. I remember venlafaxine (Effexor) at doses of 1/4 tablet (6.25mg) gave me tachycardia, high blood pressure and severe headache. Imipramine at 25mg and nortriptyline at 10 or 25mg (can't remember which) gave me irregular heartbeats and other side effects. Desipramine (Norpramin) at 10mg made me feel faint all the time.
Dextromethorphan makes me feel like I'm under the influence of something much stronger. I should get tested for that enzyme problem unless that is expensive. I remember taking codeine with my friend when I was a teenager and it didn't even affect me but my friend said he could feel it. Then I read the other day that codeine is a prodrug which is converted by CYP2D6 to morphine and if you are a poor metaboliser, it won't convert over to morphine very much, if at all.
I really wonder if I am a poor metaboliser. It could be, or it could be that I'm just very sensitive to medications.It does seem that I am tolerant of medications which aren't metabolised by that enzyme such as benzodiazepines and tianeptine, etc. I could build up quite a tolerance when I used to drink.
I took two tianeptine last night. At first I couldn't sleep and then felt quite strange. My lips and fingers felt numb and I felt a bit fuzzy headed, but that could have been anxiety.
Even now I still feel fuzzy headed and have a bit of dry mouth, but not depressed at this time.
Tianeptine feels too short-acting. I wish they could make an extended release formulation to avoid the interdose problems.
poster:sukarno
thread:474445
URL: http://www.dr-bob.org/babble/20050901/msgs/550133.html