Posted by darkhorse on August 18, 2005, at 3:06:24
In reply to Re: Sibutramine » darkhorse, posted by ed_uk on August 17, 2005, at 4:33:50
> Hi DH,
>
> Sibutramine was tested as an AD but was found to be ineffective. I wonder why?
>
> Also, I've always wondered whether sibutramine, like SSRIs, Effexor and Cymbalta, might actually cause weight *gain* in the long run - at least in some people. I've known people to put on LOADS of weight on SSRIs and SNRIs!
>
> Kind regards
>
> ~EdHi ED,
I do not believe that by just labeling a medication "SNRI", means that all under this title are identical.I think that each drug is unique,even if they are very chemically closely related (Mianserin/Mirtazapine-Sulpiride/Amisulprid).
In the case odf the SNRIs there is a clear difference in the potency of 5ht/ne/da uptake inhibition :
Venlafaxine is much stronger on 5ht,followed by Duloxetine which also has a more potency towards 5ht.
However both Milnacipran and Sibutramine are more NE poten, and "maybe" that is why they do not produce weight gain on the long run..etc.All the best!
DH
poster:darkhorse
thread:533825
URL: http://www.dr-bob.org/babble/20050816/msgs/543321.html