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Re: Propranolol (Inderal) for PTSD

Posted by sdb on July 30, 2005, at 8:07:43

In reply to Re: Propranolol (Inderal) for PTSD » Phillipa, posted by ed_uk on July 30, 2005, at 4:22:13

Hi all!

It depends what you take. If you take propranolol you will feel tired. Nadolol has a similar structure to propranolol is as effective, is more hydrophil (!), has a long half-life.

Slow-Trasicor or Trasicor (Oxprenolol) definately does not sedate, it even stimulates the sympathicus but also
diminish it, when a lot of adrenaline is in your bood (ISA).

The structure of almost every betablocker is related to adrenaline itself.

Both are treatments for performance anxiety, panic... with less side-effects

A dose-ranging study to evaluate the beta 1-adrenoceptor selectivity of bisoprolol.
Eur J Clin Pharmacol. 1991;40(2):135-9.
PMID: 1676675 (effectiveness of nadolol to catecholamines (!))

Oxprenolol in the treatment of examination stress.
Curr Med Res Opin. 1976;4(3):241-3.
PMID: 780063 (comparism between this betablocker and a bz with better results for oxprenolol)

Beneficial effect of nadolol on anxiety-induced disturbances of performance in musicians: a comparison with diazepam and placebo.
Am Heart J. 1984 Oct;108(4 Pt 2):1150-5.
PMID: 6148877 (comparism between nadolol and diazepam, better results with nadolol)

Please be aware:
(quality of studies may often vary (statistics, accomplishment...)

all the best

sdb


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