Posted by ed_uk on July 22, 2005, at 16:41:58
In reply to Dose related akathesia, posted by Declan on July 22, 2005, at 16:22:48
Hi Declan,
When I took Largactil, very low doses causes no akathisia, a moderate dose caused INTENSE akathisia.
>There used to be a viewpoint that akathesia and other side effects of APs actually got less at higher doses. Any truth in this?
I guess it might be true when comparing *very* high doses of high potency neuroleptics with *exceptionally* high doses! Say, 200mg Haldol might cause less akathisia than 100mg because the higher dose would be more anticholinergic. D2 antagonism would already have pretty much 'maxed out' at 100mg.
In general, akathisia gets much worse as the dose is increased. Decreasing the dose can often resolve the akathisia.
>And you're right Ed. Difficult to handle stroke victims. Easy to imagine.
It's often claimed that patients with schizophrenia are more tolerant of AP side effects than patients who don't have schizophrenia. I'm not convinced! IMO, patients who suffer from schizophrenia are simply more likely to have difficulty expressing their side effects to their pdocs....their side effects are more likely to be attributed to their underlying illness and ignored.
~Ed
poster:ed_uk
thread:530027
URL: http://www.dr-bob.org/babble/20050718/msgs/531750.html