Posted by Mistermindmasta on July 22, 2005, at 0:12:17
In reply to Re: EXACTLY, posted by SLS on July 19, 2005, at 8:41:38
> I guess we'll never know for sure the extent to which this young person was depressed before beginning the Cymbalta treatment.
> A number of years ago, I stood alone here on Psycho-Babble pleading that people become more aware of the possibility that Prozac causes suicide. Of course, I implicated other drugs as well, but Prozac was the one focused on by the media. There are those that wanted to ascribe the few incidences to be found on Medline to akathisia. I found this to be a weak argument, as it seemed to me that the incidences of suicide were higher than those of akathisia.
> Cymbalta caused a depressed young woman to commit suicide. Now what?
> - Scott
Just want to point out that myself and several others agree that akasthisia is EXTREMELY underreported in the literature. I have NEVER had suicidal thoughts until I took compazine a few years ago for nausea. The restlessness was so incredibly horrible, but I'm lucky I was a psychologically healthy person at the time and was able to wait it out. Also, having never experiences such feelings, I had a hard time describing the way I was feeling.
However, I think another part to this suicide thing is that some people can become more impulsive / agressive while on SSRI's, if they happen to have a certain brain circuitry predisposition. Prozac I believe has the strongest effects on 5-HT3 receptors (might be wrong on that one), which can decrease dopamine in the nigrostriatal zone, causing restlessness. Combine that with some more energy and impulsive aggression in someone who's had a messed up life and there ya go...
I don't believe cymbalta's effects on other receptors are as nearly well studied as it's effect on norep and 5-ht reuptake. Maybe I just haven't come across them yet..