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Re: Severe Anxiety, Moderate Depression High Corti » SLS

Posted by Elroy on May 28, 2005, at 20:14:57

In reply to Re: Severe Anxiety, Moderate Depression High Corti » Elroy, posted by SLS on May 28, 2005, at 7:54:52

Must have been some time ago from some of the material that was passed on to me. (???)

I know that my Endo had indicated that he was aware of RU486 being a standardc therapy in "certain Cushings cases, such as those where surgery was impractical or had to be put off for a while". He also told me that he thought that it had been originally developed in Europe specifically as a treatment for Cushing's patients.

I did find one encyclopedia entry that indicated:

QUOTE: The compound was discovered by researchers at Roussel Uclaf of France in 1980 while studying glucocorticoid receptor antagonists. Clinical testing began in 1982. It was first licensed in France in 1988... END QUOTE

Possibly he was referring to earleir uses in Europe for anti-cortiso treatments in Cushing's cases.

I know that there have been a number ofclinical trials in the US concerning RU486 effects in psychotic depression cases and believe that there is either an ongoing study (or recently concluded) one involving RU486 and Bipolar Depression.

My belief is that RU486 will have the same success rate with any type of depression or anxiety that involves highly elevated cortisol due to HPA dysfunction....

Interesting comment here:

http://www.nap.edu/books/0309049490/html/229.html

"In patients with long-standing hypercortisolism not caused by Cushing's disease, however, RU 486-induced antagonism of peripheral glucocorticoid effects presumably would not be overcome. This concept was tested in a few patients with ectopic ACTH secretion and proved correct. At daily doses of 5–22 mg/kg, RU 486 reversed psychosis, hypokalemia, hypertension, weight gain, inhibition of luteinizing hormone, follicle-stimulating hormone, testosterone, thyroid-binding globulin (TBG), corticosteroid-binding protein (CBG), and T4, and restored euglycemia..."

We sparred over using it for lowering cortisol levels (and thereby possibly anxiety levels) because he kept confusing what I was talking about with the standard long-term regimen that is sued in Cushing's treatment (versus what I was talking about as a strictly short-term therapy for purposes of hopefully causing the HPA Axis to re-set and normalize cortisol secretion).


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> > Now my endo has every right to prescribe this medication as it is an FDA approved anti-cortisol medication (RU486 was first developed many years ago as an anti-cortisol treatment for Cushings patients)
>
> When did this happen? It was my impression that the FDA still allows only one indication for mifepristone (RU-486) - that of an abortifacient.
>
> On to CRH antagonists!
>
>
> - Scott


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poster:Elroy thread:502852
URL: http://www.dr-bob.org/babble/20050527/msgs/504423.html