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Venlafaxine (Effexor) and Moclobemide (Manerix) ?

Posted by ben on May 21, 2005, at 9:53:17

Hi
Does anyone have experiences with the combination of Venlafaxine with Moclobemide ? I am on 450 mg of Effexor, Lithium, Neurontin 800 mg twice daily. Effexor pooped out at 225 mg and didnt give me relief on 450 mg. 2 weeks ago I added Remeron (gradualy up to 45 mg). My mood is still bad and I think it is worser than with 200 mg of Trazodone (Desyrel). Now I think of going of the Remeron and adding Moclobemide (idea of my pdoc). Or should I wait with the Remeron or perhaps going back (directly) to Desyrel.
I read on pubMed that early onset of relief predicts the outcome of response and remisson for Remeron and that only a subtype of the catechol-o-methyltransferase (COMT) population develop response on Remeron. Perhaps I have not that kind of COMT???


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poster:ben thread:500715
URL: http://www.dr-bob.org/babble/20050521/msgs/500715.html