Posted by chemist on May 11, 2005, at 3:27:22
In reply to For Chemist: Maybe you can help me, posted by tampagirl70 on May 10, 2005, at 13:07:53
> I'm trying to figure out why I had a very odd reaction to both risperdal and geodon. My mouth got very irritated and red and sore. I tried risperdal first, then geodon, and it got worse on the geodon. Now I'm afraid that every new med I try will have the same effect on me. I just started taking Anafranil last night (25mg) and my mouth feels irritated already, but it could just be because I haven't eaten anything today and I'm not drinking enough fluids. What do you think?
hello there, chemist here...i think phillipa or link or others could give you a better read than i...from a mechanistic standpoint, the anafranil is undoubtedly contributing to your discomfort because of the large anticholinergic component associated with this particular compound; the risperidone and ziprasidone are not compounds of interest when looking at ACh/Ch and related, thus the histaminergic blockade as mentioned by phillipa - and perhaps some of the specific serotoninergic activity at subtypes within 5-HT_{1}, although quite low in general - is the only component i would consider as being the culprit...the AAPs you mention are quite effective in antagonizing D_{2} and 5-HT_{2} (broader for the 5-HT_{2})...
the ziprasidone is likely to be something that you might have inadvertantly prodded into being a bit more troublesome if you were not rather strict in taking the med with a meal or not, and this is more of an issue than with risperidone and is a fundamental issue related to the structures of the compounds....
the bottom line is that if you are overly sensitive to the dry mouth associated with almost all meds - it is given at least honorable mention is adverse effects for nearly eferything in the book and then some - you have to work with your doctor and find the variation within a theme that minimizes this facet...
as for being overly alert in re: any new med causing same, i ask first what the rationale is for going from risperidone/ziprasidone to clomipramine, as this is (to me) indicative of a rather abrupt change in your dx...the latest med in your regimen will promise to be shown the door in a greater hurry than the previous, if side effects are problematic to you. i note that my own feelings about TCAs are biased, so please get a read of what others have experienced if you and you doctor are going to go with medications in this class...in the event you wish to save some time, energy, and money in the pursuit of happiness: if you are offered amitriptyline or trimipramine, look forward to similar unpleasant effects. beyond the advice of drink plenty of fluids, be wary of intake of salts, and do not take candy from strangers, i cannot offer any other suggestions...apologies, and pardon the odd hours....all the best, chemist
poster:chemist
thread:496024
URL: http://www.dr-bob.org/babble/20050510/msgs/496296.html