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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by tampagirl70 on May 10, 2005, at 13:07:53
I'm trying to figure out why I had a very odd reaction to both risperdal and geodon. My mouth got very irritated and red and sore. I tried risperdal first, then geodon, and it got worse on the geodon. Now I'm afraid that every new med I try will have the same effect on me. I just started taking Anafranil last night (25mg) and my mouth feels irritated already, but it could just be because I haven't eaten anything today and I'm not drinking enough fluids. What do you think?
Posted by tampagirl70 on May 10, 2005, at 15:53:59
In reply to For Chemist: Maybe you can help me, posted by tampagirl70 on May 10, 2005, at 13:07:53
I'd really like your input. Thanks.
Posted by Phillipa on May 10, 2005, at 17:30:01
In reply to Re: FOR CHEMIST or LINKADGE, posted by tampagirl70 on May 10, 2005, at 15:53:59
Are they all considered an antihistamine? I know seroquel is. Yup I think it's a question for one of the experts. I know they'll chime in. Fondly, Phillipa
Posted by chemist on May 11, 2005, at 3:27:22
In reply to For Chemist: Maybe you can help me, posted by tampagirl70 on May 10, 2005, at 13:07:53
> I'm trying to figure out why I had a very odd reaction to both risperdal and geodon. My mouth got very irritated and red and sore. I tried risperdal first, then geodon, and it got worse on the geodon. Now I'm afraid that every new med I try will have the same effect on me. I just started taking Anafranil last night (25mg) and my mouth feels irritated already, but it could just be because I haven't eaten anything today and I'm not drinking enough fluids. What do you think?
hello there, chemist here...i think phillipa or link or others could give you a better read than i...from a mechanistic standpoint, the anafranil is undoubtedly contributing to your discomfort because of the large anticholinergic component associated with this particular compound; the risperidone and ziprasidone are not compounds of interest when looking at ACh/Ch and related, thus the histaminergic blockade as mentioned by phillipa - and perhaps some of the specific serotoninergic activity at subtypes within 5-HT_{1}, although quite low in general - is the only component i would consider as being the culprit...the AAPs you mention are quite effective in antagonizing D_{2} and 5-HT_{2} (broader for the 5-HT_{2})...
the ziprasidone is likely to be something that you might have inadvertantly prodded into being a bit more troublesome if you were not rather strict in taking the med with a meal or not, and this is more of an issue than with risperidone and is a fundamental issue related to the structures of the compounds....
the bottom line is that if you are overly sensitive to the dry mouth associated with almost all meds - it is given at least honorable mention is adverse effects for nearly eferything in the book and then some - you have to work with your doctor and find the variation within a theme that minimizes this facet...
as for being overly alert in re: any new med causing same, i ask first what the rationale is for going from risperidone/ziprasidone to clomipramine, as this is (to me) indicative of a rather abrupt change in your dx...the latest med in your regimen will promise to be shown the door in a greater hurry than the previous, if side effects are problematic to you. i note that my own feelings about TCAs are biased, so please get a read of what others have experienced if you and you doctor are going to go with medications in this class...in the event you wish to save some time, energy, and money in the pursuit of happiness: if you are offered amitriptyline or trimipramine, look forward to similar unpleasant effects. beyond the advice of drink plenty of fluids, be wary of intake of salts, and do not take candy from strangers, i cannot offer any other suggestions...apologies, and pardon the odd hours....all the best, chemist
Posted by tampagirl70 on May 11, 2005, at 8:35:19
In reply to Re: For Chemist: Maybe you can help me » tampagirl70, posted by chemist on May 11, 2005, at 3:27:22
I think I found out who the true culprit is behind this oral issue and the meds. i just started drinking this light minute maid raspberry passion fruit drink. i thought back to the weekend when my mouth felt better and realized that i didn't drink any of the fruit drink over the weekend. my last dose of geodon was last thursday night, so it made sense to me that the geodon was what was causing the problem. now looking back, i think it was probably the fruit drink. i'm not drinking any today and seeing how my mouth is. thanks for your input!
This is the end of the thread.
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