Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Effects of Selegiline's amphetamine metabolites? » cache-monkey

Posted by Larry Hoover on April 22, 2005, at 16:08:19

In reply to Effects of Selegiline's amphetamine metabolites?, posted by cache-monkey on April 21, 2005, at 12:24:24

> Hey all,
>
> So I'm considering trying low-dose selegiline for what I think are a cluster of symptoms related to low dopamine (smoking, ADD, past binge drinking, anhedonia, anergia).
>
> However, selegiline metabolizes into a couple of amphetamites (l-amphetamine and l-methamphetamine). I've heard that these are the "bad" isomers of the drugs. What does that mean in terms of their CNS/periphery effects?
>
> I'm particularly interested in l-methamphetamine, since, according to an in vivo study, this is substantially raised among poor CYP-2D6 metabolizers. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9797797&dopt=Abstract ... I'm an "intermediate" CYP-2D6 metabolizer, which is a lot closer to "poor" than to "extensive"/normal.]
>
> Thanks!
> cache-monkey

First off, the proportion of the selegiline that goes to these amphetamines is tiny. Really tiny. And it occurs over a period of time, so it's also a trickle. A tiny trickle.

I use selegiline myself, and I've also used amphetamines and meth (many years ago). I cannot find the slightest correspondence between the two experiences. Nor am I the least bit concerned about any toxic effects.

That's merely my opinion, of course.

Lar

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Larry Hoover thread:487473
URL: http://www.dr-bob.org/babble/20050418/msgs/488012.html