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Re: Effects of Selegiline's amphetamine metabolite Larry Hoover

Posted by Elroy on April 27, 2005, at 16:48:12

In reply to Re: Effects of Selegiline's amphetamine metabolites? cache-monkey, posted by Larry Hoover on April 23, 2005, at 14:17:47

Just started selegiline at low dose. Prescription is for 5mg but I'm actually starting at 2.5 mg (half tablet). Testing showed my norepinephrine levels to be really low (like 26 pg/ml with a reference range of 80 - 520). Worse it seems that my body has "adjusted" to those low levels and that any major boost of NE (Effexor, Cymbalta, higher dose tyrosine, higher dose DLPA, intense exercise, etc.) cause a serious increase in anxiety, neuropathy type pains and bring on severe prostatitis type symptoms.

Like Larry, am also on Neurontin for the neuropathy type pains, but am hopeful to get on to Lrica instead if it ever gets released to the US market.

Additionally, am on Ambien for sleep aid and Xanax XR for anxiety.

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> Actually, I use it p.r.n.
>
> If I use it continuously, insomnia and acid reflux get too high. It's stimulant, without being buzzy. Antidepressant, yes, but more on the apathy and fatigue and depressed cognitive function.
>
> I'm just bringing it back "online" after starting on gabapentin (for neuropathic pain). I wanted to understand the gabapentin all by itself, so I discontinued selegiline for about a month. So far, the combination is really good for me.
>
> Before I took selegiline, I researched it thoroughly, and I could not find any evidence for anything other than theoretical risk....not in vivo risk.
>
> I just keep my dose really low so I don't have to concern myself with MAO-A inhibition.
>
> Lar


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