Posted by ixus on April 8, 2005, at 6:29:26
In reply to Re: Never parnate with an SSRI » ixus, posted by smith562 on April 8, 2005, at 5:51:58
> > Selegiline is more activating and anxiogenic than tranylcypromine.
> > /ixus
>
> I know they are both non-hydrazine MAOIs and can be anxiogenic for some ... selegiline does metabolize to amphetamines. The problem with parnate was that I would never add an SSRI and risk serontonin syndrome/death. The data with selegiline at 10mg or below suggest it is fairly safe (thousands of parkinson's patients get selegiline and an ssri every year), although no guarentees.
>
> I am hoping low dose zoloft and klonopin will offset any anxiety induced by selegilne. Hopefully someone out there has maybe tried this and can give me feedback.
>
> Thanks Ixus! Hope you are well. Please keep
> the post coming!
Hi Smith,
why not to use tranlycypromine + benzo only? Have you tried that combo? I know that tranylcypromine + clonazepam does not work well for me (tranylcypromine seems to potentiate depression induced by clonazepam).
I have a good success with tranylcypromine 30 + clorazepate 20 mg (similar to diazepam). However in order to get rid of benzo I will try phenelzine.
I tried selegiline in a high dose (60 mg). I doubt whether you will see any effect at 10 mg.
Safety is always a concern, I would not go on 1+ serotonergic drugs (though as you noticed 10 mg of selegiline should not have any influence on serotonin).Could you describe your feelings of phenelzine? What was the dose?
/ixus
poster:ixus
thread:481264
URL: http://www.dr-bob.org/babble/20050408/msgs/481547.html