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Re: Clonazepam (Klonopin) - steady state concentration sdb

Posted by ed_uk on March 21, 2005, at 13:15:06

In reply to Re: Clonazepam (Klonopin) - steady state concentration, posted by sdb on March 21, 2005, at 12:59:27

Hi!

>Efficacy is only 12 hours (unfortunately) so *it is not proportional with half-life.*

That applies to most drugs, particularly in short-term use, there are other factors which affect duration of action as well as half-life.

Anyway, based on the half-life of clonazepam, it would make sense to dose it 2-3 times a day. Giving it as a single daily dose would produce large fluctuations in the plasma concentration.

Best regards,
Ed.

PS. Just out of interest, what country are you from?


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URL: http://www.dr-bob.org/babble/20050317/msgs/473628.html