Posted by ed_uk on March 15, 2005, at 8:34:48
In reply to Re: week 2 - Rebox, posted by sabre on March 13, 2005, at 23:05:38
Hi Sabre!
>............binned the stuff.
Good choice :-)
>Ed, I'm really wary of the TCAs because of their effect on the heart etc.
TCAs often cause sinus tachycardia. I doubt that desipramine would be much more likely to cause sinus tachycardia than reboxetine though - possibly slightly more likely because it's weakly anticholinergic. Sinus tachycardia is not a serious arrhythmia, expect in people with coronary heart disease. I've had sinus tachycardia for the last 2 years, mainly because I'm so unfit. I stopped lofepramine for a while, heart rate was still about 100 at rest.
Very rarely, TCAs can cause life-threatening arrhythmias such as torsades de pointes. If you suffer from certain types of heart disease, TCAs are best avoided. Also, if you have a family history of sudden death, you'd need to be evaluated for congenital long QT syndrome before being prescribed a TCA.
If you can get hold of desipramine and you'd like to try it, I'd suggest starting out with a very low dose, say 10mg/day, given the dramatic effects of low-dose reboxetine.
>I found that the R seemed to constantly stimulate the heart which in the first few days makes you very energetic but after that you start to feel laboured.
.....but do you think you felt laboured due to the effect it was having on your mood? ie. rather than on your heart.
>The one thing that was v. useful with Reboxetine was the improvement of nerve pain.
You suffer from neuropathic pain? What caused it? TCAs can be helpful for neuropathic pain.
>...Lamictal
Could be useful. Lamictal is sometimes prescribe off-label for neuropathic pain.
OK, I'm gonna shut up about desipramine now because I'm starting to sound like a sales rep. To be fair, I would be a bit concerned about you trying it because there's a chance that it might make you more depressed, like reboxetine, after all it is essentially an NRI. I don't know what's wrong with reboxetine though. How come SLS got more depressed on rebox when he benefits from desip? I think we have a lot to learn about rebox, it could be affecting some receptors that we don't even know about yet.
Best regards,
Ed.
poster:ed_uk
thread:469486
URL: http://www.dr-bob.org/babble/20050312/msgs/471224.html