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Re: week 2 - Rebox

Posted by sabre on March 13, 2005, at 23:05:38

In reply to Re: week 2 - Rebox » sabre, posted by ed_uk on March 12, 2005, at 14:44:41

Thanks again, Scott and Ed.
I've stopped blubbering into the keyboard and binned the stuff.

My mood started to shift about a day later and I woke up without that desperation, which was a relief. I sort of over shot the mark though and my sympathetic system went into overdrive. Got real chatty, hyped and felt like I could climb mountains. I couldn't sleep and every stressful thought induced a spurt of adrenaline.
I've been taking Propranolol to keep the adrenaline under control.

Ed, I'm really wary of the TCAs because of their effect on the heart etc. Running matters to me. I thought Reboxetine was pretty neutral in this regard. I read a PubMed study that looked at cyclists on R. It had no significant effect on their performance. The trouble with these studies is that they always pick 'normal' people and they give them a one off dose (4mg) and then they go off for a long bike ride. I couldn't find anything else to guide me in this respect...other than rats being more motivated to stay afloat in a bucket of water...

I found that the R seemed to constantly stimulate the heart which in the first few days makes you very energetic but after that you start to feel laboured. My running kept getting slower and slower to the point it was hard to even jog. With the dose increase I felt like the blood was pooling in my ankles when I started to run and it took a bit to get going.
As for the depression...it was profound.

I was curious about mood stabilisers because I read that they can help if you have no luck with ADs. Lamictal seemed the most side effect free but then some people spoke of fatigue, dizziness etc
The one thing that was v. useful with Reboxetine was the improvement of nerve pain. It took it away completely at the .5 x 3/day and it all came back straight away with the withdrawal of Reboxetine.

Back to the drawing board......
Sabre


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