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Klono not nearly as effective as X? (Oth. Benzos?)

Posted by cache-monkey on March 14, 2005, at 14:18:42

Hey all,

I had a panic attack in early January. Full-blown. Prior, I had been suffering from GAD and cyclothymia/soft BP. I had been using Xanax 0.25 prn before Jan, and immediately after the panic attack I started taking Xanax at 1-1.5 mg/day.

About 10 days later, my p-doc switched me to Klonopin, which makes sense from a number of perspectives. (Longer half-life => theoretically less rebound anxiety, less addiction potential.) The first two weeks, due to some stressful on-site job interviews, I started Klonopin at 1 mg/day (divided up over the day) and took Xanax at about 1 mg/day while on-site. While home, I'd go off Xanax and feel alright, but still with a lot of anxiety.

I went up to 1.5 mg/day on the Klonopin a couple weeks ago and haven't taken any Xanax for about 3+ weeks. My anxiety gradually worsened and neared panic status again last week. I also have been feeling very slowed down (that might be a consequence of upping my Lithium to 900 mg/day -- that's the only other drug I'm on right now.) Finally, I broke down and took a Xanax (0.25 mg) and boom anxiety gone.

So it seems that 1.5 mg/day of Klonopin is not nearly as effective as a slightly lesser amount of Xanax. My understanding was that they are supposed to be about equivalent in terms of dosages (0.5 mg X = 0.5 mg K).

Is it the case that it just varies between individuals? I.e., for some is Xanax just more effective at a comparable dose? Is a bezo just a benzo?

I'm a little averse to going up further on the Klonopin and would like to consider switching benzos with my p-doc. I'm thinking of Xanax XR, but am worried about the eventual taper, which I think is harder with Xanax. How about Ativan? Valium?

[Alternatively, some of my anxiety might be attributable to being in a "mixed state". I'm having trouble getting the Lithium to a therapeutic dose due to thirst and tiredness, so adding Depakote is another possibility...]

Any advice would be greatly appreciated.





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