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Re: SSRI's that are also 5HT2C-receptor antagonists? cache-monkey

Posted by Sarah T. on March 7, 2005, at 21:53:19

In reply to Re: SSRI's that are also 5HT2C-receptor antagonists? Sarah T., posted by cache-monkey on March 6, 2005, at 14:33:10

Hi. Thanks for the link to Sheldon Preskorn's site. I logged onto that site a few years ago and thought it was so good, and I've been meaning to go back to it ever since.

I might very well be mistaken about the 5HT2C receptor. I thought that those receptors were dense in the frontal or prefrontal lobes, and that when they are antagonised, there wouldn't be such a huge increase in serotonin there, which would mean that there wouldn't be such a large corresponding decrease in dopamine in the same location. I thought that the frontal lobes were very important in motivation, so I don't want to lower dopamine in that part of the brain. I am like a limp rag on Celexa, mentally as well as physically, so I assumed that Celexa must be agonising that receptor.

I also didn't realize that antagonism of that receptor caused increased appetite. I always thought it was one of the histamine receptors that was responsible for that. Perhaps it's both?

I had a paradoxical reaction to Trazodone. It made me anxious and sleepless. That was a huge disappointment for me. I really wanted to take a non-benzodiazapine sleep aid that would have some mild antidepressant efficacy as well. I haven't had those genetic tests yet. I probably will, but I think they will just confirm what has been observed clinically over numerous failed medication trials, especially those involving drug combinations. Wouldn't it be great if we could have custom-made medicines, tailored to suit our individual genes and biochemisty?

Thanks again for your help. By the way, that's a cool screen name, Cache-Monkey!




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