Posted by cache-monkey on March 4, 2005, at 12:43:39
In reply to SSRI's that are also 5HT2C-receptor antagonists?, posted by Sarah T. on March 2, 2005, at 2:37:29
How come the curiousity with the 5-HT2c, in particular?
My experience with the 2c is that antagonists => reduced anxiety, weight increase, decreased sexual function (particularly in males). [I have references to back all of these effects up, if you're interested.]
So, while you might get better anxiolysis with a 2C blocker, I think that's where (for me, at least) the most troublesome side effects come from.
I'm not sure about Serzone's direct effect on the 5-HT2c receptor (I didn't think it had one), but it's metabolite (mCPP) is a strong _agonist_ of that receptor.
In terms of SSRIs, both Celexa and Prozac show strong binding affinities for the 2c receptor. Zoloft seems to be neutral. (http://www.ocfoundation.org/ocf_0030.htm) I don't know anything about the others.
Hope this helps,
cache-monkey> I posted this above but that thread seems to have been swallowed by archiving, so here it is again: Is Prozac the only ssri that antagonizes 5HT2C receptors? I think it was Linkage who said that Prozac is both an agonist and antagonist at the 5HT2C receptor. So, other than Remeron, Trazodone, Prozac (sort of), and some of the atypical AP's, what other meds do this? Oh, I think Serzone might have been mentioned, but isn't that one of the ones that's half and half, like Prozac?
poster:cache-monkey
thread:465324
URL: http://www.dr-bob.org/babble/20050304/msgs/466462.html