Posted by ed_uk on February 12, 2005, at 20:25:09
The blockade of serotonin (5-HT) and norepinephrine (NE) transporters in vitro and in vivo by the dual 5-HT/NE reuptake inhibitors duloxetine and venlafaxine was compared. Duloxetine inhibited binding to the human NE and 5-HT transporters with K(i) values of 7.5 and 0.8 nM, respectively, and with a K(i) ratio of 9. Venlafaxine inhibited binding to the human NE and 5-HT transporters with K(i) values of 2480 and 82 nM, respectively, and with a K(i) ratio of 30.
'Of particular interest were the findings that paroxetine, generally thought of as a selective serotonin transporter antagonist, possesses moderately high affinity for the norepinephrine transporter and that venlafaxine, which has been described as a "dual uptake inhibitor", possesses weak affinity for the norepinephrine transporter.'
Lol, so Effexor's basically an SSRI after all!
Ed.
poster:ed_uk
thread:456946
URL: http://www.dr-bob.org/babble/20050212/msgs/456946.html