Posted by Michael Bell on February 9, 2005, at 21:37:41
In reply to Re: Are any of these new GABA meds effective?, posted by aazospiro on February 2, 2005, at 0:45:03
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Uhh, no. You post actually proved my point. Klonopin is an agonist of the BDZ receptor. It does NOT act as an agonist of the GABA alpha subunits themselves. This is why it has anti-seizure, sedating, and anti-insomniac properties rather than acting as a pure anxiolytic. There is NO PURE GABA AGONIST on the market yet.Ahmmm correction there mister,
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> Klonopin [Clonazepam] differs from the rest of the benzodiazepines in that in is a partial agonist at the BDZ receptors.
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> Interesting thing about thses neurotransmitters [from my many many readings] is that they display what I refer to as the "see-saw effect"
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> Specifically, GABAergic drugs loose their euphorigenic effects, calming properties which quickly turns to severe irritabilitywith chronic use, but add a dopaminergic agent like selegiline or Sinemet or even better a stim and its all back again like if you used it for the first time.
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> And while on the subject of stimulants, all the chit chat about glutamate antagonists like DXM being used for stim tolerance [which I cant dispute] hasn't anyone considered the effects that T-4 or T3 have on the responsiveness of adrenergic/ dopaminergic receptors. Apparently even though no receptor density changes are evident, the response is augmented and only very tiny doses are needed of the latter.
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> Certaintly food for thought
poster:Michael Bell
thread:448915
URL: http://www.dr-bob.org/babble/20050207/msgs/455705.html