Posted by djmmm on December 9, 2004, at 18:27:16
In reply to Re: MAOIs and aggression, posted by jclint on December 9, 2004, at 17:03:52
> Yeah its very interesting. Interesting theories on the cause of the anti-anxiety properties of MAOIs.
>
> I'm a little suspicious of some of the statements though:
>
> "In the treatment of social phobia, characterized by an exaggerated fear of exposing oneself to the scrutiny of others, the response rate of phenelzine is 60–70% (142,145). Moclobemide has similar efficacy (146)."
>
> I know there is little research into Moclobemide and SP, but I'm strongly skeptical about this drug. I certainly haven't seen any anecdotes of people getting a robust anti-sp effect from it.This is the study:
Versiani M, Nardi AE, Mundim FD, Alves AB, Liebowitz MR, Amrein R. Pharmacotherapy of social phobia. A controlled study with moclobemide and phenelzine. Br J Psychiatry 1992;161:353-360.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1393304
Pharmacotherapy of social phobia. A controlled study with moclobemide and phenelzine.
Versiani M, Nardi AE, Mundim FD, Alves AB, Liebowitz MR, Amrein R.
In a double-blind, parallel group trial, 78 subjects with social phobia received moclobemide (a new reversible inhibitor of monoamine oxidase A) phenelzine, or placebo. After eight weeks, both active drugs-phenelzine somewhat more than moclobemide--were clinically and statistically significantly more effective than placebo, as assessed by rating scales. There was some further improvement between weeks 8 and 16, particularly in the moclobemide group; at week 16, 82% of the moclobemide and 91% of the phenelzine-treated patients were almost asymptomatic. Moclobemide was, however, much better tolerated than phenelzine. Patients withdrawn from active drugs had relapsed by week 24, providing additional support for the efficacy of the active drugs.
poster:djmmm
thread:425286
URL: http://www.dr-bob.org/babble/20041206/msgs/426892.html