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MAOIs and aggression

Posted by ed_uk on December 6, 2004, at 13:48:36

Hi,

In animals, MAO type A deficiency has been associated with aggressive behaviour. Similarly, humans will low platelet MAO activity appear to be more aggressive. I was wondering how this might relate to treatment with an MAO inhibitor such as Nardil, Marplan, Parnate or Manerix/Aurorix.

To those who have taken an MAOI, did it produce an increase in aggression?

Someone did once tell me that Parnate made them unsympathetic. Perhaps the clinical efficacy of MAOIs in making people less anxious and less sensitive might also tend to make them more aggressive under certain circumstances.

.........If you are not interested in what I'm saying stop here, if you are interested then read on...........

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Here are some quotes from studies on PubMed.............

'MAO A knock-out mice have elevated brain levels of serotonin, norephinephrine, and dopamine and manifest aggressive behavior similar to human males with a deletion of MAO A.'

'There was lower (platelet) MAO activity among violent offenders than among nonviolent offenders.'

'Violent behavior has been associated with certain personality traits like poor impulse control, sensation seeking, and monotony avoidance, which predispose to increased risk for violent acts. Low platelet monoamine oxidase (MAO) activity has been found in subjects with such traits, as well as in imprisoned violent offenders.'

'Patients who were diagnosed as psychopaths according to the criteria of Cleckley had significantly lower platelet MAO activity than the control group.'

'We studied a large sample of male children from birth to adulthood to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not. ................. Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems.'

'Criminal offenders displayed significantly lower MAO activity in comparison to noncriminals. High levels of norm-breaking behavior in adolescence were associated with adult high impulsiveness, low socialization, and low platelet MAO activity in both male and female subjects.'


Ed.


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poster:ed_uk thread:425286
URL: http://www.dr-bob.org/babble/20041206/msgs/425286.html