Posted by jboud24 on November 4, 2004, at 9:47:15
In reply to Re: Classical Neuroleptics: Dysphoria in pill form!, posted by linkadge on November 3, 2004, at 11:40:28
Linkage,
The main reason LSD works to produce creativity is due to the fact that through stimulation of the 2a/c receptors, a very powerful tonic control is forced upon the DA system. In other words LSD and related agonists drastically reduce the release of dopamine in the mPFC region of the brain. This effect induces creative thought processes by reducing the stereotypical nature of dopamine and allowing the user to 'think outside the usual box that dopamine pkaces on our creativity circuits. Additionally, while some people feel a sense of inner peace and creativity, many, many people panic when exposed to LSD proposed to be related to increased 2c agonism and enhanced glutamatergic transmission at the metabotropic glu receptor mGlu5. As for Risperdal, it antagonizes the 2a and 2c receptors thereby provoking anxiolysis, sedation, and relaxation.
The dysphoria this user felt was no doubt due to the rapid and fairly complete inactivation of the 5-HT2a/c, dopamine D2/D3 receptors to an extent that the neurons were not yet ready for. Risperdal is the strongest neuroleptic on the US market IIRC, and the highest recommened dose is 12mg for psych in-patients, again IIRC. But to a drug-naive mind, such a profound and instant shift in brain function no doubtedly caused these trip-like, weakening, and dysphoric characteristic.
Moral of Story: Don't mess around with doses of neuroleptics unless you are both familiar with the effects or are very well versed in dose titration for the specific drug you are taking,
Justin
poster:jboud24
thread:411009
URL: http://www.dr-bob.org/babble/20041103/msgs/411586.html