Posted by lostforwards on November 3, 2004, at 13:47:17
In reply to Re: Classical Neuroleptics: Dysphoria in pill form!, posted by linkadge on November 3, 2004, at 11:40:28
> Many of the psychadelics act on the 5-ht2a recetpor, being agonists.
>
> THe only problems is that strong 5-ht2a agonism by LSD and others leads to a very rapid downregulation in the 5-ht2a receptors.
>
> If you suddenly introduce a 5-ht2a antagonist (risperidone strong 5-ht2a antagonist) into the picture, the 5ht-2a receptor gets virtually no serotonin, which can create severe states of panic.
>
> Potent 5-ht2a agonism creates feelings of empowerment and "universal understanding"
> even a "cosmic contiousness" if you will.
>
> But potent 5-ht2a antagonism can lead to feelings of being nonexistant. (often happens at the end of a LSD trip) creating sudden and severe panic.
>
> This is not to even mention messing with the dopamine system.
>
>
> Linkadge
>
>
>I might be wrong but I think antagonism of the 5-ht2a receptor leads to an increase in striatal dopamine..I think that's part of the reason why atypicals that block that receptor have less chance of causing TD.
poster:lostforwards
thread:411009
URL: http://www.dr-bob.org/babble/20041103/msgs/411144.html