Re: Tricyclics and SSRI augmentation

Posted by linkadge on October 31, 2004, at 9:57:00

In reply to Tricyclics and SSRI augmentation, posted by RetiredYoung on October 31, 2004, at 9:37:24

Oftentimes a TCA is added to a SSRI to augment the SSRI.
Clomipramine is very much like a SSRI in its actions. Ie, it mainly effects the serotonin pump.
Usually a noradrenic TCA is added to an SSRI to provide additional antidepressant responce.
If your problem is mainly depression, then perhaps you could add a bit of nortyptaliine to the clomipramine in order to get a greater effect on the norepinephrine neurotransmitter.
I think that adding a SSRI might not be beneficial in that your depression does not seem to be fully responsive to serotogenic medications.
You might even consider adding wellbutrin to the clomipramine.
You have to ask yourself which symptoms of depression are you still experiencing.
1. Sadness, anxiety, insomnia,
(responsive to additional serotonin)
or
2. Anhedonia, low energy, low motivation, apathy, poor concentation etc.
(responsive to noradrenic medications)

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Tricyclics and SSRI augmentation RetiredYoung 10/31/04
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