Posted by Iansf on October 28, 2004, at 20:17:13
In reply to GHB is proven safe. » Michael Bell, posted by Carlos C on October 28, 2004, at 0:26:15
Could you please clarify something for me. Even if GHB is not dangerous on its own, is it dangerous with alcohol, or were those stories trumped up as well? Thanks.
> > Regarding GHB, I haven't tried it, but I imagine it's a true social phobia killer since it increases GABA release (indirectly through stimulation of GHB receptors), increases serotonin turnover rate (not to be confused with increasing serotonin levels) and has rewarding properties via mu-opioid activity. Also, the dopamine release upon waking is a plus. But I'm staying away from it until they have a cheap, extended release version with proven safety.
> There is a company currently working on a formulation to extend GHBs duration. Besides that, safety has been proven. If you "over-dose" you just get very good restful sleep. This should never happen if you accurately measure your dose. It's less toxic than Tylenol. In fact it shows no toxicity in the human body and has many positve physical and mental benefits to boot. Unfotunately it is extremely expensive though. Lucily my health coverage covers it (for now).
> As has been emphasized, the overall safety of GHB is well-established, and no deaths attributable to GHB have been reported over the forty year period that this compound has been in use [Vickers, 1969; Chin and Kreutzer, 1992].Of all adverse reactions that had been reported in the United States all were followed by rapid and complete recovery [Chin and Kreutzer, 1992]. Unlike a large proportion of other drugs including alcohol and even Tylenol, GHB has no toxic effects on the liver, kidney or other organs [Vickers, 1969; Chin and Kreutzer, 1992]. One program of sleep therapy using six to eight grams daily for a period of eight to ten days produced no side effects. Vickers  even reports that doses as high as twenty to thirty grams per twenty-four hour period have been used for several days without negative consequences In the Canadian studies of narcolepsy mentioned earlier, the nightly use of two to six teaspoons (one teaspoon equaling roughly 2.5 grams) for several years resulted in no reports of long-term adverse effects, or problems with issues of addiction or dependence. In one of these studies, one patient inadvertently ingested fifteen teaspoons without adverse consequence “other than deep sedation and headache the next day” [Chin and Kreutzer, 1992]. And in France, sub-anesthetic oral doses were used by “a large number of patients for about six years” without untoward effect [Laborit, 1972].